Mariola Tortosa

Mariola Tortosa obtained her B.S. in Chemistry from the Universidad Autónoma de Madrid (UAM) in 1999. She then joined the group of Dr. R. Fernández de la Pradilla at the Instituto de Química Orgánica General (Madrid, Spain) to carry out her graduate work on the development of new asymmetric methods using chiral sulfoxides. In 2004, she received the Lilly Award for PhD students. In 2005, she moved to The Scripps Research Institute in Florida (USA) to work as a Postdoctoral Fellow with Prof. William Roush. Her research in Florida was directed toward completion of the total synthesis of the antitumor agent Superstolide A using a transannular Diels–Alder strategy. In 2008 she returned to the Instituto de Química Orgánica General (Madrid, Spain) as a Research Assistant. In 2011 she started her independent research at the Universidad Autónoma de Madrid as a Ramón y Cajal Fellow. More recently, she received the ERC-Starting Grant awarded by the European Research Council to work on the project “Design and Applications of Unconventional Borylation Reactions”. Her research interests include boron chemistry, asymmetric catalysis and the synthesis of natural products.

FULL LIST OF PUBLICATIONS           E-MAIL: MARIOLA.TORTOSA@UAM.ES

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Mariola Tortosa’s experience and awards:

Education and Research Experience
  • 2011-: Assistant Professor (Ramón y Cajal Researcher), UAM, Madrid
  • 2008-2011: Research Associate, CSIC, Madrid
  • 2005-2008: Postdoctoral Associate, The Scripps Research Institute, Florida

       Advisor: Prof. William R. Roush
       Projects: “Total Synthesis of Superstolide A” and “Synthesis of inhibitors of monocarboxylate transporter 1 (Mct-1)”

  • June 1999-Jan. 2005: Graduate Student, CSIC, Madrid

          Advisor: Prof. Roberto Fernández de la Pradilla
          Thesis title: “Application of Vinyl Sulfoxides in Claisen rearrangements, Diels-Alder reactions and nucleophilic additions” (Cum Laudem, January 2005).

  • August 2001-Dec. 2001: Visiting-Student, Ohio State University

            Advisor: Prof. Robert S. Coleman
            Project: “Total Synthesis of Antitumor Agents Oximidines I and II”

  • September 1994-June 1999: Bachelor’s Degree in Chemistry (Honors), UAM, Madrid
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Fellowships and Awards
  • Thieme Journal Award 2015
  • Eli Lilly Young Researcher Award 2014
  • RSEQ Young Investigator Award 2014
  • ERC Starting Grant (2013)
  • JSP Fellowship 48th Bürgenstock Conference 2013
  • 2010- Ramón y Cajal Contract
  • 2008-2010 Juan de la Cierva Contract (Research Associate)
  • 2005-2007 Postdoctoral Fellowship (Spanish government)
  • 2001-2005 Predoctoral Fellowship (Spanish government)
  • 2004 Eli Lilly Ph.D. award
  • 1999 Universidad Autónoma de Madrid Award (for the top students in Chemistry)
  • 1997-2000 Fellowship from the Madrid Regional Government

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HIGHLIGHTED PUBLICATIONS OF Mariola Tortosa as GROUP Leader:

· Regio- and Stereospecific Copper-Catalyzed Substitution Reaction of Propargylic Ammonium Salts with Aryl Grignard Reagents. Guisan-Ceinos, M.; Martín-Heras, V.; Tortosa, M.* J. Am. Chem. Soc. 2017, 139, 8448.

· Enantioselective Synthesis of Cyclobutylboronates via a Copper-Catalyzed Desymmetrization Approach. Manuel Guisán-Ceinos, Alejandro Parra, Victor Martín-Heras, Mariola Tortosa,* Angew. Chem. Int. Ed. 2016, 55, 6969-6972.

· Copper-Catalyzed Borylative Aromatization of p-Quinone Methides: Enantioselective Synthesis of Dibenzylic Boronates. Carlos Jarava-Barrera, Alejandro Parra, Aurora López, Fabio Cruz-Acosta, Daniel Collado-Sanz, Diego J. Cárdenas, Mariola Tortosa,*  ACS Catal. 2016, 6, 442-446. (highlighted in Synfacts 2016, 12, 0291)

· Copper-Catalyzed Silylation of p-Quinone Methides: New Entry to Dibenzylic Silanes, Aurora López, Alejandro Parra,  Carlos Jarava-Barrera, Mariola Tortosa*Chem. Comm. 2015, 51, 17684-17687.

· para-Quinone Methide: a New Player in Asymmetric Catalysis, Alejandro Parra, Mariola Tortosa*, ChemCatChem 2015, 7, 1524–1526.

·  Insight into the Copper-Catalyzed Borylation of Strained Alkenes, Alejandro Parra, Aurora López, Sergio Díaz-Tendero, Laura Amenós, José Luis Garcia-Ruano, Mariola Tortosa*, Synlett 2015, 26, 494. Young Investigators Issue

· Copper-catalyzed diastereo- and enantioselective desymmetrization of cyclopropenes: synthesis of cyclopropylboronates, Alejandro Parra, Laura Amenós, Manuel Guisán-Ceinos, Aurora López, José Luis Garcia-Ruano, Mariola Tortosa*J. Am. Chem. Soc. 2014, 136, 15833-15836.

· New Methods in Organic Synthesis via Copper-Catalyzed Borylation Reactions: Stereoselective Synthesis of 1,4-Diols and Vinylboronates, Ricardo Alfaro, Alejandro Parra, José Alemán, Mariola Tortosa*, Synlett 2013, 24, 0884-0812. Invited account.

· Copper(I)-Catalyzed Formal Carboboration of Alkynes: Synthesis of Tri- and Tetrasubstituted Vinylboronates, Ricardo Alfaro, Alejandro Parra, José Alemán, José Luis Garcia-Ruano, Mariola Tortosa*J. Am. Chem. Soc. 2012, 134, 15165-15168. (Highlighted in http://www.organic-chemistry.org/abstracts/lit3/792.shtm.)