Mariola Tortosa

Mariola Tortosa obtained her B.S. in Chemistry from the Universidad Autónoma de Madrid (UAM) in 1999. She then joined the group of Dr. R. Fernández de la Pradilla at the Instituto de Química Orgánica General (Madrid, Spain) to carry out her graduate work on the development of new asymmetric methods using chiral sulfoxides. In 2004, she received the Lilly Award for PhD students. In 2005, she moved to The Scripps Research Institute in Florida (USA) to work as a Postdoctoral Fellow with Prof. William Roush. Her research in Florida was directed toward completion of the total synthesis of the antitumor agent Superstolide A using a transannular Diels–Alder strategy. In 2008 she returned to the Instituto de Química Orgánica General (Madrid, Spain) as a Research Assistant. In 2011 she started her independent research at the Universidad Autónoma de Madrid as a Ramón y Cajal Fellow. More recently, she received the ERC-Starting Grant awarded by the European Research Council to work on the project “Design and Applications of Unconventional Borylation Reactions”. Her research interests include boron chemistry, asymmetric catalysis and the synthesis of natural products. In December 2017, she was promoted to Associate Proffesor.

FULL LIST OF PUBLICATIONS           E-MAIL: MARIOLA.TORTOSA@UAM.ES

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Mariola Tortosa’s experience and awards:

Education and Research Experience
  • 2022 – present: Professor, UAM, Madrid
  • 2017 – 2022: Associate Professor, UAM, Madrid
  • 2011 – 2017: Assistant Professor (Ramón y Cajal Researcher), UAM, Madrid
  • 2008 – 2011: Research Associate, CSIC, Madrid
  • 2005 – 2008: Postdoctoral Associate, The Scripps Research Institute, Florida

       Advisor: Prof. William R. Roush
       Projects: “Total Synthesis of Superstolide A” and “Synthesis of inhibitors of monocarboxylate transporter 1 (Mct-1)”

  • June 1999-Jan. 2005: Graduate Student, CSIC, Madrid

          Advisor: Prof. Roberto Fernández de la Pradilla
          Thesis title: “Application of Vinyl Sulfoxides in Claisen rearrangements, Diels-Alder reactions and nucleophilic additions” (Cum Laudem, January 2005).

  • August 2001-Dec. 2001: Visiting-Student, Ohio State University

            Advisor: Prof. Robert S. Coleman
            Project: “Total Synthesis of Antitumor Agents Oximidines I and II”

  • September 1994-June 1999: Bachelor’s Degree in Chemistry (Honors), UAM, Madrid
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Fellowships and Awards
  • 2021 Barluenga Medal
  • 2020 ERC Consolidator Grant
  • 2015 Thieme Journal Award
  • 2014 Eli Lilly Young Researcher Award
  • 2014 RSEQ Young Investigator Award (Spanish Royal Society of Chemistry)
  • 2013 ERC Starting Grant
  • 2013 JSP Fellowship 48th Bürgenstock Conference
  • 2011-2017 Ramón y Cajal Fellow (competitive contract from the Spanish government)
  • 2008-2011 Juan de la Cierva Fellow (competitive contract from the Spanish government)
  • 2005-2007 MEC Postdoctoral Fellow (Spanish government), Scripps Florida, USA
  • 2004 Eli Lilly Ph.D. award
  • 2001-2005 MEC Predoctoral Fellow (Spanish government), CSIC, Spain
  • 1999 Universidad Autónoma de Madrid, Best Undergraduate in Chemistry Award
  • 1997-2000 Fellowship from the Madrid Regional Government
Invited Lectures

70. Ischia Advanced School of Organic Chemistry, Ischia (Italy), September 2024.

69. Catalysis for Organic Synthesis- ACS Publications Symposium, Viena (Austria), August 2024.

68. 9th EuChemS Chemistry Congress (ECC-9), Dublin (Ireland), July 2024.

67. XXIX Biennial Meeting of the Spanish Organic Chemistry Division, Tenerife (Spain), June 2024.

66. 57th Bürgenstock Conference, Brunnen (Switzerland), April 2024.

65. 28th Felix Serratosa Conference, Barcelona, January 2024.

64. 3rd Japanese-Spanish Symposium on Organic Synthesis, San Sebastian, October 2023.

63. UCB Pharma, webminar, September 2023.

62. Groupe d’Études en Chimie Organique (GECO63), Kerjouanno (France), September 2023.

61. Adam Mickiewicz University, Poznan (Poland), June 2023.

60. 23rd Tetrahedron Symposium,  Gothenburg (Sweden), June 2023.

59. Universidad del Pais Vasco, San Sebastian (Spain), March 2023.

58. Instituto de Productos Naturales y Agrobiología, Tenerife (Spain), November 2022.

57. Barluenga Conference, Oviedo (Spain), October 2022.

56. The Batsheva de Rothschild Seminar on Strong Bond Activation Meeting, Dead Sea (Israel), October 2022.

55. Amgen, Thousand Oaks (California), July 2022 (invited seminar and consulting sessions).

54. RSEQ-European Journal of Organic Chemistry symposium, May 2022 (invited webminar).

53. Universidad de Zaragoza, May 2022.

52. Institut Català d’Investigació Química (ICIQ), Tarragona, April 2022.

51. University of Glasgow, January 2022 (invited webminar).

50. International Symposium on Synthesis and Catalysis, Evora, September 2021.

49. University of Toronto, July 2021 (invited webminar).

48. EJOC, Modern Synthetic Chemistry (seminar series), April 2021 (invited webminar).

47. University of Michigan, March 2021 (invited webminar).

46. RSEQ Seminar, January 2021 (invited webminar).

45. University of Barcelona, November 2020 (invited webminar).

44. LIMA laboratory, Université de Strasbourg, April 2020 (invited webminar).

43. 53rd Sheffield Stereochemistry meeting, Sheffield, January 2020.

42. New Frontiers in Synthetic Chemistry, Royal Society of Chemistry, London, November 2019.

41. “Journées de Chimie Organique” (JCO), Paris, October 2019.

40. EFMC-ASMC 19, Advances in Synthetic and Medicinal Chemistry, Athens, September 2019.

39. UAM- Summer School: Hacia la sinergia perfecta: la conexión entre investigación académica e industrial como herramienta de innovación. Miraflores de la Sierra, July 2019.

38. University of Geneva, June 2019.

37. University of Basel, Basel, February 2019.

36. RSC Heterocyclic & Synthesis Group January Meeting 2019, The Institute of Cancer Research, London, January 2019.

35. University of Zurich, Zurich, December 2018.

34. 6th Brazil-Spain Workshop on Organic Chemistry, Oviedo, October 2018.

33. University of Münster, July 2018.

32. GlaxoSmithKline, Stevenage, June 2018.

31. University of Tokyo, Tokyo, May 2018.

30. Institute of Transformative Bio-Molecules, Nagoya, May 2018.

29. Osaka University, May 2018.

28. The Second Japanese-Spanish Symposium on Organic Synthesis, Kyoto, May 2018

27. Girona Seminar 2018, Girona, April 2018.

26. ETH, Zurich, March 2018.

25. Novartis, Basel, March 2018.

24. Université Catholique de Louvain, Louvain La Neuve, February 2018.

23. Instituto de Investigaciones Químicas, Sevilla, February 2018.

22. Barluenga Lectureship 2017, Oviedo, November 2017.

21. ICIQ School, Tarragona, September 2017.

20. German-Spanish Symposium on Frontiers in Chemistry, Tarragona, September 2017.

19. 11th International School of Organometallic Chemistry (ISOC), San Benedetto del Tronto, September 2017.

18. 20th European Symposium on Organic Chemistry (ESOC), Cologne, July 2017.

17. Centro de Investigación en Química Sostenible, Huelva, May 2017.

16. CINQUIMA, Instituto Universitario, Valladolid, April 2017.

15. Instituto universitario de bio-organica Antonio Gonzalez, Tenerife 2017.

14. 6 Jornadas de la Red de Catálisis Asimétrica – Red CASI, Palma de Mallorca, October 2016.

13. 9th Asian-European Symposium on Metal-Mediated Efficient Organic Synthesis (AES), Stockholm, September 2016.

12. EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC), Manchester UK, September 2016.

11. 11th Spanish-Italian Symposium on Organic Chemistry SISOC-XI, San Sebastian, July 2016.

10. Universidad de Zaragoza, Zaragoza, December 2015.

9. 7th Spanish Portuguese Japanese Organic Chemistry Symposium, Sevilla, June 2015.

8. Janssen Pharmaceuticals, Toledo, May 2015.

7. New perspectives in asymmetric and organometallic synthesis 4th edition, Valencia, October 2014

6. XI Simposio de Investigadores Jóvenes, Bilbao, November 2014.

5. Instituto de Química Orgánica General, CSIC, Madrid 2014.

4. 6th EuCheMS Organic Division Young Investigators Workshop, Cyprus 2014.

3. Eli Lilly, Alcobendas 2014.

2. XXV Reunión Bienal de Química Orgánica, Eli Lilly conference, Alicante 2014.

1. Institut Català d’Investigació Química (ICIQ), Tarragona 2013.

HIGHLIGHTED PUBLICATIONS OF Mariola Tortosa as GROUP Leader:

· Quiros, I; Martin, M; Gomez-Mendoza, M; Cabrera-Afonso, MJ; Liras, M; Fernandez, I; Novoa, L.; Tortosa, M.* Isonitriles as Alkyl Radical Precursors in Visible-Light Mediated Hydro– and Deuterodeamination Reactions. Angew. Chem. Int. Ed. 2024, e202317683.

· Teresa Ojeda, J.; Velado, M.; Fernandez de la Pradilla, R.; Viso Beronda, A.; Lozano-Fabuel, B.; Tortosa, M.*, Enantioselective Suzuki Cross-Coupling of 1,2-Diboryl Cyclopropanes. Chem. Sci., 2023, 14, 1575-1581. DOI: 10.1039/D2SC05789A.

· Stereoselective Diboration of Spirocyclobutenes: A Platform for the Synthesis of Spirocycles with Orthogonal Exit Vectors. Novoa, L.; Trulli, L.; Parra, A.; Tortosa, M.*  Angew. Chem. Int. Ed. 2021, 60, 11763

· Harnessing the Elusive 1,4-Reduction of Vinyl Epoxides through Copper Catalysis. Amenós, L; Nóvoa, L.; Trulli, L.; Arroyo-Bondía, A.; Parra, A.; Tortosa, M.* ACS Catal. 2019, 9, 6583-65-87.

·Strained boronates do the trick. Parra, A.; Tortosa, M.* Nature Chemistry  2019, 11, 104.

· Stereospecific Synthesis of a-Hydroxy-Cyclopropylboronates from allylic epoxides. Amenos, L.; Trulli, L.; Novoa, L.; Parra, A.; Tortosa, M.* Angew. Chem. Int. Ed.  2019, 58,  1.

· Regio- and Stereospecific Copper-Catalyzed Substitution Reaction of Propargylic Ammonium Salts with Aryl Grignard Reagents. Guisan-Ceinos, M.; Martín-Heras, V.; Tortosa, M.* J. Am. Chem. Soc. 2017, 139, 8448.

· Enantioselective Synthesis of Cyclobutylboronates via a Copper-Catalyzed Desymmetrization Approach. Manuel Guisán-Ceinos, Alejandro Parra, Victor Martín-Heras, Mariola Tortosa,* Angew. Chem. Int. Ed. 2016, 55, 6969-6972.

· Copper-Catalyzed Borylative Aromatization of p-Quinone Methides: Enantioselective Synthesis of Dibenzylic Boronates. Carlos Jarava-Barrera, Alejandro Parra, Aurora López, Fabio Cruz-Acosta, Daniel Collado-Sanz, Diego J. Cárdenas, Mariola Tortosa,*ACS Catal. 2016, 6, 442-446. (highlighted in Synfacts 2016, 12, 0291)

· Copper-catalyzed diastereo- and enantioselective desymmetrization of cyclopropenes: synthesis of cyclopropylboronates, Alejandro Parra, Laura Amenós, Manuel Guisán-Ceinos, Aurora López, José Luis Garcia-Ruano, Mariola Tortosa*, J. Am. Chem. Soc. 2014, 136, 15833-15836.

· Copper(I)-Catalyzed Formal Carboboration of Alkynes: Synthesis of Tri- and Tetrasubstituted Vinylboronates, Ricardo Alfaro, Alejandro Parra, José Alemán, José Luis Garcia-Ruano, Mariola Tortosa*, J. Am. Chem. Soc. 2012, 134, 15165-15168. (Highlighted in http://www.organic-chemistry.org/abstracts/lit3/792.shtm.)

Synthesis of Syn and Anti 1,4-Diols by Copper Catalyzed Boration of Allylic Epoxides, Tortosa, M*, Angew. Chem. Int. Ed. 2011, 50, 3950-3953. (Highlighted in Synform 2011, 08.)